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Small-Molecule NNMT Inhibitor
5-Amino-1MQ
5MG per vial
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quinolinium salt rather than a peptide, and acts as a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT catalyses transfer of a methyl group from S-adenosylmethionine to nicotinamide, yielding 1-methylnicotinamide and S-adenosylhomocysteine. 5-Amino-1MQ is a substrate-site binder that competes with nicotinamide itself, with in vitro assays reporting an IC50 near 1.2 uM and selectivity over related methyltransferases of the NAD+ salvage pathway.
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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Compound signature
From confirmed structure
286.1g/mol
Molar mass
12atoms
Heavy atoms
Atomic composition
C10H11N2·I (iodide salt)
- C10
- H11
- N2
Characterised targets
- NNMT
Research applications
Because NNMT consumes both nicotinamide, a precursor feeding the NAD+ salvage pathway, and SAM, the principal cellular methyl donor, inhibition has been utilised as a chemical tool to probe where NAD+ availability and methylation capacity intersect. Assays in 3T3-L1 adipocyte culture have measured lipogenesis and intracellular 1-methylnicotinamide concentrations as paired readouts of target engagement. Rodent studies have examined NNMT inhibition in diet-induced obesity models, where the enzyme is abundantly expressed in white adipose tissue and liver, and separate work in aged mice has investigated skeletal muscle stem cell proliferation and fusion. NNMT overexpression across several tumour types has additionally made the enzyme a subject of in vitro oncology investigation.
Formulation and handling
Unlike the lyophilised peptides elsewhere in this catalogue, 5-Amino-1MQ is a small-molecule salt supplied as a crystalline powder, typically the iodide, and dissolves readily in water or DMSO without the gentle swirling a peptide cake requires. Confirm the salt form on the certificate of analysis before calculating molarity, since the counter-ion contributes materially to formula weight and the chloride and iodide forms differ substantially in mass.
Intended use
5-Amino-1MQ is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 5MG
- Molecular formula
- C10H11N2·I (iodide salt)
- Molar mass
- 286.11 g/mol (iodide salt; 159.21 g/mol for the free cation)
- CAS number
- 42464-96-0
- Molecular targets
- NNMT
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
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