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Albumin-Binding GHRH Analogue
CJC-1295 DAC
5MG per vial
CJC-1295 DAC is a synthetic analogue of growth hormone-releasing hormone built on the GHRH(1-29) scaffold, carrying four substitutions — D-Ala2, Gln8, Ala15 and Leu27 — plus a thirtieth residue, lysine, bearing an N-epsilon-3-maleimidopropionamide group known as the Drug Affinity Complex. It agonises the GHRH receptor, a class B GPCR on anterior pituitary somatotrophs, coupling through Gs to adenylyl cyclase, raising intracellular cAMP and triggering calcium-dependent exocytosis of growth hormone secretory granules. The maleimide reacts with the free thiol of Cys34 on serum albumin to form a covalent conjugate, and that bioconjugation is what distinguishes this form from CJC-1295 without DAC, otherwise known as modified GRF(1-29).
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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Compound signature
From confirmed structure
3647g/mol
Molar mass
258atoms
Heavy atoms
Atomic composition
C165H269N47O46
- C165
- H269
- N47
- O46
Characterised targets
- GHRHR
Sequence
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(epsilon-3-maleimidopropionamide)-NH2
Research applications
Each substitution addresses a specific liability of native GHRH: D-Ala at position 2 blocks dipeptidyl peptidase-4 cleavage, Gln8 removes an asparagine deamidation site, Leu27 removes a methionine oxidation site, and Ala15 is reported to have been introduced to raise receptor potency. Published pharmacokinetic characterisation reports a terminal half-life in the region of six to eight days, reflecting the circulating albumin-bound reservoir, against the minutes-scale clearance of unmodified GHRH. That difference in residence time is why the compound recurs as a comparator in work distinguishing continuous from pulsatile stimulation of the somatotroph axis, where growth hormone and IGF-I concentrations are tracked over a timescale of days rather than minutes and pulse amplitude and trough concentrations are the readouts of interest.
Formulation and handling
Supplied as a lyophilised powder. The maleimide is a chemically reactive handle rather than an inert tag: reconstitution in buffers containing free thiols such as DTT, beta-mercaptoethanol or cysteine will consume it, and maleimides hydrolyse to the unreactive maleamic acid under alkaline conditions, so a near-neutral to slightly acidic solvent preserves albumin-conjugating capacity. Treat it as a thiol-reactive reagent rather than a plain peptide.
Intended use
CJC-1295 DAC is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 5MG
- Molecular formula
- C165H269N47O46
- Molar mass
- 3647.2 g/mol
- CAS number
- 863288-34-0
- Molecular targets
- GHRHR
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
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