CJC-1295 No DAC

10MG per vial

CJC-1295 No DAC, catalogued in the literature as Modified GRF (1-29), is a synthetic 29-residue analogue of the bioactive N-terminal fragment of human growth hormone-releasing hormone. It is C-terminally amidated and carries four substitutions relative to the native sequence: D-Ala at position 2, Gln for Asn at 8, Ala for Gly at 15 and Leu for Met at 27 — the first blocking dipeptidyl peptidase-4 cleavage, the second removing an asparagine deamidation site and the fourth removing the oxidation-labile methionine. It is an agonist at the growth hormone-releasing hormone receptor (GHRHR), a class B G protein-coupled receptor on anterior pituitary somatotrophs that couples through Gαs to adenylyl cyclase, raising intracellular cAMP and activating protein kinase A.

Endocrine Axis Metabolic Signalling

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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.

Compound signature

From confirmed structure

3368g/mol

Molar mass

238atoms

Heavy atoms

Atomic composition

C152H252N44O42

C152
H252
N44
O42

Characterised targets

GHRHR

Sequence

Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

Research applications

The parent compound CJC-1295 extends the same tetrasubstituted backbone with a thirtieth residue, lysine, whose side-chain amine carries a maleimidopropionyl group; this maleimide reacts with Cys34 of serum albumin to form a covalent conjugate. The present molecule omits that lysine and linker entirely, and the pair has been utilised to separate GHRHR receptor pharmacology from carrier-mediated plasma residence. In vitro work with pituitary cell preparations and GHRHR-expressing lines has characterised cAMP accumulation and CREB phosphorylation downstream of receptor occupancy, together with the transcriptional arm running through Pit-1 to the GH gene. Because the albumin conjugate persists in circulation on a multi-day timescale while the unconjugated analogue does not, cell and rodent studies have used the two side by side to examine episodic rather than continuous receptor stimulation. The unconjugated form is also frequently co-applied with ghrelin receptor (GHS-R1a) agonists such as ipamorelin or GHRP-6, which engage an entirely separate receptor, in designs intended to probe the interaction between the two secretagogue pathways.

Formulation and handling

Supplied as a lyophilised cake; the C-terminal amide blocks carboxypeptidase trimming and the D-Ala2 residue blocks DPP-4 cleavage at the N-terminus, making the chain more resistant to exopeptidase attack than native GHRH(1-29), but it remains a 29-residue, arginine- and lysine-rich peptide that adsorbs to glass and polypropylene from dilute solution. Introduce diluent slowly down the vial wall rather than directly onto the cake and swirl rather than vortex, since shearing and foaming are the principal causes of recovery loss with chains of this length.

Intended use

CJC-1295 No DAC is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.

Specification

Presentation: Vial
Labelled strength: 10MG
Molecular formula: C152H252N44O42
Molar mass: 3367.9 g/mol
Molecular targets: GHRHR
Appearance: Lyophilised powder
Storage: 2–8 °C sealed, −20 °C long term

Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.

Certificates of analysis

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