PT-141

10MG per vial

PT-141 (bremelanotide) is a synthetic cyclic heptapeptide melanocortin agonist and the C-terminally deamidated metabolite of Melanotan II, structurally identical to its parent apart from a free carboxylic acid in place of the terminal carboxamide. That single substitution at the C-terminus measurably shifts the receptor profile: it acts as an agonist principally at MC3R and MC4R, with weaker MC1R activity than Melanotan II and negligible activity at MC2R. Signalling proceeds through Gs-coupled cAMP accumulation, and because the molecule is centrally penetrant, most mechanistic work concerns MC4R populations in the brain rather than peripheral melanocortin receptors.

Endocrine Axis

StockLive

In stock

Available to ship today

Pricing on request

Prices are still being set. Add what you need to your cart and request a quote from there — we will come back with current pricing and availability, usually within one business day.

Cart

Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.

Compound signature

From confirmed structure

1025g/mol

Molar mass

74atoms

Heavy atoms

Atomic composition

C50H68N14O10

Characterised targets

MC1R
MC3R
MC4R

Sequence

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Research applications

Rodent work has localised its activity to hypothalamic and medial preoptic MC4R populations, and microdialysis studies in rats have characterised a rise in extracellular dopamine in the medial preoptic area following melanocortin agonism, with dopamine receptor blockade abolishing the associated behavioural readouts — establishing an MC4R-to-dopamine sequence as the pathway under study. Studies in hormone-primed ovariectomised female rats have used it to examine appetitive sexual behaviours as an MC4R-dependent readout, with direct infusion into the medial preoptic area but not the ventromedial hypothalamus reproducing the effect. Earlier preclinical programmes investigated melanocortin agonism in models of haemorrhagic shock and ischaemia-reperfusion injury, where MC1R- and MC3R-mediated modulation of inflammatory signalling was the mechanism being tested; those lines were not carried forward. In receptor pharmacology it serves as a probe for central versus peripheral melanocortin signalling and as the counterpart to Melanotan II in structure-activity studies of the C-terminal amide.

Formulation and handling

Supplied lyophilised, generally as the acetate salt, and it redissolves in water without organic co-solvent. It differs from Melanotan II by roughly one dalton at the C-terminus and is indistinguishable from it by appearance, so identity should be confirmed against the mass and retention time on the lot certificate of analysis; the free carboxylate also lowers the isoelectric point relative to the parent amide, which matters when transferring ion-exchange or reversed-phase methods between the two.

Intended use

PT-141 is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.

Specification

Presentation: Vial
Labelled strength: 10MG
Molecular formula: C50H68N14O10
Molar mass: 1025.2 g/mol
CAS number: 189691-06-3
Molecular targets: MC1R, MC3R, MC4R
Appearance: Lyophilised powder
Storage: 2–8 °C sealed, −20 °C long term

Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.

Certificates of analysis

None published yet

Every lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.

Slot 1
Awaiting upload
The certificate for the next tested lot will appear here. Until then, ask us for the one matching your vial.
Slot 2
Awaiting upload
The certificate for the next tested lot will appear here. Until then, ask us for the one matching your vial.
Slot 3
Awaiting upload
The certificate for the next tested lot will appear here. Until then, ask us for the one matching your vial.