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Adamantane-Modified Semax Analogue
Adamax
10MG per vial
Adamax is a synthetic analogue of Semax, the Russian-developed heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro, described as carrying N-terminal acetylation together with an adamantane (tricyclodecane) moiety. Acetylation blocks the N-terminus against aminopeptidase attack, and the rigid, strongly lipophilic adamantyl cage is a long-standing medicinal chemistry motif used to raise lipophilicity and metabolic stability. No primary published characterisation of Adamax itself exists, so its structure as supplied, its receptor interactions and its stability profile have not been independently established; the design rationale is inferred entirely from the parent peptide.
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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Research applications
Research interest derives from Semax, which is more precisely the ACTH(4-7) fragment extended by a C-terminal Pro-Gly-Pro tripeptide than a full ACTH(4-10) analogue. Studies in rats have reported specific Semax binding in basal forebrain tissue and have measured BDNF and NGF transcript levels, BDNF protein and TrkB phosphorylation in hippocampus, with melanocortin receptor signalling and CREB-dependent transcription proposed as the upstream route. Investigators working with Adamax are typically asking whether these Semax-associated readouts are altered by the acetyl and adamantyl modifications. Because no peer-reviewed study has reported on Adamax directly, that comparison remains an open experimental question rather than a characterised property of the compound.
Formulation and handling
Supplied as a lyophilised powder. The adamantyl group is far more lipophilic than anything in the parent Semax sequence, so dissolution behaviour should not be assumed to match Semax; verify the solid has genuinely dissolved rather than dispersed before use, and confirm identity and structure against the certificate of analysis, as there is no reference literature against which to check the material independently.
Intended use
Adamax is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 10MG
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
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Slot 3
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The certificate for the next tested lot will appear here. Until then, ask us for the one matching your vial.
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