DSIP

5MG per vial

DSIP is a nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, isolated by the Schoenenberger-Monnier group in Basel from the cerebral venous blood of rabbits undergoing low-frequency electrical stimulation of the intralaminar thalamic nuclei; the amino acid analysis, sequence and synthesis of the nonapeptide were published in 1977. It is markedly acidic and amphiphilic for its length, and a saturable transport mechanism at the blood-brain barrier has been demonstrated in the vascularly perfused guinea pig brain. No DSIP receptor, precursor protein or encoding gene has ever been cloned, so unlike almost every other neuropeptide its mechanism remains formally unassigned; proposed involvement of NMDA and opioid receptors, and of MAPK cascade components on the basis of sequence homology to glucocorticoid-induced leucine zipper, is inferential rather than established.

Neuropeptide Signalling

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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.

Compound signature

From confirmed structure

848.8g/mol

Molar mass

60atoms

Heavy atoms

Atomic composition

C35H48N10O15

Sequence

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)

Research applications

The original rabbit experiments measured EEG spectral power in the delta band and motor activity following intraventricular infusion, and later laboratories reported difficulty reproducing the sleep-architecture findings; Kovalzon and Strekalova's 2006 review in the Journal of Neurochemistry, titled "Delta sleep-inducing peptide (DSIP): a still unresolved riddle", set out the case that the sleep-factor hypothesis remains poorly documented, in part because no gene, protein or receptor has been isolated. Away from sleep, rodent work has examined DSIP in the context of the stress axis by measuring plasma ACTH and corticosteroid responses to imposed stressors, and in oxidative-stress models by quantifying malondialdehyde accumulation and transcript levels of SOD1 and GPX1 across age cohorts of rats. Separate work has examined its influence on somatostatin release, which one report attributed to a dopaminergic mechanism. With a reported in vitro half-life of roughly fifteen minutes, it has additionally served as a substrate for studies of neuropeptide turnover.

Formulation and handling

Supplied lyophilised, typically as an acetate or trifluoroacetate salt; with aspartate, glutamate and a free C-terminal carboxylate it is distinctly acidic and dissolves readily in neutral aqueous buffer without organic co-solvent. The N-terminal tryptophan is the residue to protect, being the most photolabile and oxidation-prone side chain in the sequence, so keep reconstituted material shielded from light and away from peroxide-bearing diluents.

Intended use

DSIP is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.

Specification

Presentation: Vial
Labelled strength: 5MG
Molecular formula: C35H48N10O15
Molar mass: 848.8 g/mol
CAS number: 62568-57-4
Appearance: Lyophilised powder
Storage: 2–8 °C sealed, −20 °C long term

Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.

Certificates of analysis

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