MOTS-C

50MG per vial

MOTS-c is a 16-residue peptide encoded not in nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene (MT-RNR1), making it one of a small set of mitochondrial-derived peptides. Its best-characterised mechanism is indirect rather than receptor-mediated: it inhibits the folate cycle and the de novo purine biosynthesis tethered to it, causing intracellular accumulation of the intermediate AICAR, which in turn allosterically activates AMP-activated protein kinase. Under metabolic stress it additionally translocates from the mitochondrion to the nucleus, where it binds antioxidant response element (ARE) sequences directly and acts in concert with the stress-responsive transcription factor NRF2.

Mitochondrial Biology Senescence & Ageing Models

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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.

Compound signature

From confirmed structure

2175g/mol

Molar mass

153atoms

Heavy atoms

Atomic composition

C101H152N28O22S2

C101
H152
N28
O22
S2

Sequence

MRWQEMGYIFYPRKLR

Research applications

Cell-based work has characterised AMPK activation and downstream GLUT4 trafficking in skeletal muscle myotubes, with a later study reporting that mitochondrial fusion is required for that trafficking step, since inhibiting the fusion GTPases MFN2 and OPA1 abrogated it. The nuclear arm has been dissected structurally: translocation in response to glucose restriction, serum deprivation or oxidative stress depends on the hydrophobic 8-YIFY-11 core, while transcriptional activity at ARE-containing promoters such as HMOX1 and NQO1 requires the basic 13-RKLR-16 motif, with alanine substitution of either motif abolishing the corresponding function. Studies in rodent models have examined it as an exercise-responsive signal and looked at glucose handling in diet-challenged animals. Human population genetics has drawn separate attention to the East Asian-specific m.1382A>C variant (rs111033358), which substitutes glutamine for lysine at residue 14 and has been investigated for associations with metabolic and muscular phenotypes in Northeast Asian cohorts.

Formulation and handling

Supplied lyophilised. Two methionines (positions 1 and 6) plus a tryptophan at position 3 make this sequence unusually oxidation-prone, so reconstituted material is best handled with minimal headspace air and split into single-use aliquots; methionine sulfoxide formation shows up as a +16 Da species by MS and is the usual explanation for a shouldered or split reversed-phase peak.

Intended use

MOTS-C is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.

Specification

Presentation: Vial
Labelled strength: 50MG
Molecular formula: C101H152N28O22S2
Molar mass: 2174.6 g/mol
CAS number: 1627580-64-6
Appearance: Lyophilised powder
Storage: 2–8 °C sealed, −20 °C long term

Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.

Certificates of analysis

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