Move to inspect
Pineal-Derived AEDG Tetrapeptide
Epithalon
10MG per vial
Epithalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly, designed at the St Petersburg Institute of Bioregulation and Gerontology as a minimal defined sequence abstracted from epithalamin, a crude polypeptide extract of bovine pineal gland. It has no identified cell-surface receptor. The mechanism proposed by Khavinson and colleagues is instead nuclear and direct: at four residues the peptide is small enough to enter the nucleus, and it is modelled as binding in the major groove of DNA at specific promoter sequences — among them the promoter of hTERT, the gene encoding the catalytic subunit of telomerase — behaving less like a receptor ligand than like a minimal sequence-recognising regulator.
In stock
Available to ship today
Pricing on request
Prices are still being set. Add what you need to your cart and request a quote from there — we will come back with current pricing and availability, usually within one business day.
Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Compound signature
From confirmed structure
390.4g/mol
Molar mass
27atoms
Heavy atoms
Atomic composition
C14H22N4O9
- C14
- H22
- N4
- O9
Sequence
Ala-Glu-Asp-Gly (AEDG)
Research applications
The 2003 report from Khavinson's group applied Epithalon to telomerase-negative cultured human fetal fibroblasts and assayed hTERT transcript levels, telomerase enzymatic activity and telomere length; a companion paper from the same group the following year addressed replicative capacity, reporting additional population doublings beyond the usual culture limit. Rodent work from the same institute has examined survival distributions, spontaneous tumour incidence and nocturnal melatonin output in ageing rats and mice, with separate lines of work addressing circadian marker rhythms. Independent replication was scarce for two decades, which makes the most useful recent reference point a 2025 Biogerontology paper from Brunel University London: it treated normal human mammary epithelial cells and fibroblasts alongside the 21NT and BT474 breast carcinoma lines and used qPCR and immunofluorescence to distinguish hTERT-dependent telomere extension from alternative lengthening of telomeres, reporting the ALT contribution as largely confined to the cancer lines. A correction to that paper's figures was published in November 2025. Researchers should read the older literature with the caveat that it is concentrated in a single laboratory.
Formulation and handling
At 390 g/mol across four residues this behaves in solution more like a small molecule than a chain peptide: it dissolves quickly in water or neutral buffer and is not prone to the shear sensitivity, aggregation or surface adsorption that complicate handling of longer sequences. Two of the four residues are acidic, so unbuffered reconstituted solutions sit on the acidic side, and peptides of this class are commonly supplied as an acetate salt — take net peptide content from the lot certificate of analysis rather than inferring it from gross mass.
Intended use
Epithalon is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 10MG
- Molecular formula
- C14H22N4O9
- Molar mass
- 390.35 g/mol
- CAS number
- 307297-39-8
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
Slot 1
Awaiting upload
The certificate for the next tested lot will appear here. Until then, ask us for the one matching your vial.
Slot 2
Awaiting upload
The certificate for the next tested lot will appear here. Until then, ask us for the one matching your vial.
Slot 3
Awaiting upload
The certificate for the next tested lot will appear here. Until then, ask us for the one matching your vial.
Also in the range
