Epithalon

50MG per vial

Epithalon, also written Epitalon, is a synthetic tetrapeptide of sequence Ala-Glu-Asp-Gly, developed by Vladimir Khavinson's group as a defined four-residue abstraction of epithalamin, a polypeptide preparation from bovine pineal gland. Unlike a conventional peptide agonist it has no identified receptor. Its proposed mode of action is nuclear: work from the originating laboratory models the tetrapeptide entering the nucleus and engaging the major groove of DNA at defined promoter regions, including the promoter of hTERT, which encodes the catalytic subunit of telomerase, so that it is characterised as a minimal transcription-factor-like regulator rather than a ligand.

Senescence & Ageing Models

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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.

Compound signature

From confirmed structure

390.4g/mol

Molar mass

27atoms

Heavy atoms

Atomic composition

C14H22N4O9

Sequence

Ala-Glu-Asp-Gly (AEDG)

Research applications

Cell-culture work published by the originating group in 2003 exposed telomerase-negative human fetal fibroblasts to the peptide and measured hTERT expression, telomerase activity and telomere length; a separate paper from the same laboratory the following year reported cultures continuing past the usual number of population doublings before senescence. In animals, the same institute has run ageing cohorts of rats and mice, recording survival, spontaneous tumour frequency and pineal melatonin rhythms. The largest caveat for anyone reading this body of work is its concentration in one laboratory; the most substantial independent contribution to date is a 2025 Biogerontology study from Brunel University London, which applied the peptide to normal human mammary epithelial cells and fibroblasts and to the 21NT and BT474 breast carcinoma lines and used qPCR and immunofluorescence to separate hTERT-mediated telomere elongation from alternative lengthening of telomeres, finding the ALT component largely restricted to the cancer lines. That paper carries a published figure correction dated November 2025.

Formulation and handling

With a mass of 390 g/mol over four residues, this is closer to a small molecule than to a chain peptide: it goes into water or neutral buffer readily and does not require the gentle reconstitution technique that longer sequences need to avoid shear and adsorption losses. Both glutamate and aspartate are present, so unbuffered solutions are acidic, and material of this type is generally filled as an acetate salt — net peptide content should be taken from the certificate of analysis for the lot rather than assumed from the gross fill.

Intended use

Epithalon is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.

Specification

Presentation: Vial
Labelled strength: 50MG
Molecular formula: C14H22N4O9
Molar mass: 390.35 g/mol
CAS number: 307297-39-8
Appearance: Lyophilised powder
Storage: 2–8 °C sealed, −20 °C long term

Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.

Certificates of analysis

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