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C-Terminal Tripeptide of α-MSH
KPV
20MG per vial
KPV is the tripeptide Lys-Pro-Val, corresponding to residues 11–13 at the C-terminus of α-melanocyte-stimulating hormone. It retains the fragment of α-MSH associated in the literature with modulation of inflammatory signalling while lacking the His-Phe-Arg-Trp core message sequence that drives pigmentation and the broader melanocortin responses. Its mechanism is genuinely contested: part of the literature attributes activity to melanocortin receptors MC1R and MC3R, while the most-cited experimental work reports that KPV suppresses NF-κB nuclear translocation and MAP kinase activation from inside the cell following transporter-mediated uptake, explicitly without requiring melanocortin receptor engagement.
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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Compound signature
From confirmed structure
342.4g/mol
Molar mass
24atoms
Heavy atoms
Atomic composition
C16H30N4O4
- C16
- H30
- N4
- O4
Characterised targets
- PepT1 (SLC15A1) (uptake transporter)
Sequence
Lys-Pro-Val (KPV)
Research applications
The most-cited experimental result is the 2008 Gastroenterology report by Dalmasso and colleagues that KPV enters intestinal epithelial and immune cells through the proton-coupled oligopeptide transporter PepT1 (SLC15A1) — a transporter normally confined to small intestine but induced in colon during inflammation — and that nanomolar concentrations inhibited NF-κB and MAP kinase activation in Caco2-BBE and HT29-Cl.19A intestinal epithelial cells and in Jurkat T cells, assessed by NF-κB luciferase reporter, Western blot, real-time RT-PCR and ELISA. The same work examined KPV in DSS- and TNBS-induced murine colitis models. Because PepT1 uptake is a transporter-mediated route rather than a receptor-mediated one, KPV is also used as a probe substrate in studies of PepT1 handling and of colonic PepT1 induction. Separately, α-MSH C-terminal fragments including KPV have been reported to show direct antimicrobial activity against organisms such as Candida albicans and Staphylococcus aureus in culture.
Formulation and handling
KPV is supplied in two chemically distinct forms — the free acid (Lys-Pro-Val-OH) and the C-terminal amide (KPV-NH2) — and published work does not always specify which was used; the figures given here are for the free acid, and the certificate identifies the form actually present. It is a short, highly water-soluble peptide with no cysteine and therefore no disulfide to preserve, making it among the more forgiving peptides in the catalogue to reconstitute.
Intended use
KPV is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 20MG
- Molecular formula
- C16H30N4O4
- Molar mass
- 342.4 g/mol
- CAS number
- 67727-97-3
- Molecular targets
- PepT1 (SLC15A1) (uptake transporter)
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
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