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Synthetic Tuftsin Analogue Heptapeptide
Selank
11MG per vial
Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Its first four residues reproduce tuftsin exactly — the tetrapeptide liberated by proteolysis of the IgG heavy chain — while the appended Pro-Gly-Pro tripeptide is reported to slow exopeptidase cleavage and extend the survival of the parent motif. No high-affinity receptor has been definitively identified for Selank; the clearest direct biochemical action reported is concentration-dependent inhibition of the enkephalin-degrading enzymes of human serum, which retards hydrolysis of Leu- and Met-enkephalin.
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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Compound signature
From confirmed structure
751.9g/mol
Molar mass
53atoms
Heavy atoms
Atomic composition
C33H57N11O9
- C33
- H57
- N11
- O9
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
Research applications
Because no single binding site accounts for its activity, rodent work on Selank has largely characterised its transcriptional footprint. In rat frontal cortex, PCR profiling has reported altered expression of genes involved in GABAergic neurotransmission, among them the GABA-A receptor subunit genes Gabra6, Gabrb1 and Gabrb3 alongside the transporter genes Slc6a1 and Slc6a11. Separately, RNA-sequencing has been used to map hippocampal gene expression in rats in the early hours after acute restraint stress, a study notable for reporting substantial transcriptional change under stress but no significant hippocampal change when the peptide was given to unstressed animals. Reflecting its tuftsin ancestry, further work has quantified changes in the expression of chemokine, cytokine and receptor genes in murine spleen after a single injection, with Bcl6 — together with its target and corepressor genes — among those reported to shift. Region-specific changes in serotonin and catecholamine turnover have also been measured in rodent brain tissue, though whether these are direct or downstream of the GABAergic and enkephalinergic effects remains unresolved in the literature.
Formulation and handling
A small, highly hydrophilic heptapeptide carrying two basic residues (Lys, Arg) and no aromatic side chains — it dissolves readily in water or aqueous buffer and needs no DMSO or other organic co-solvent, unlike the acylated peptides handled alongside it. The lyophilised cake is hygroscopic and nearly invisible against the glass, so allow the vial to equilibrate to room temperature before opening and add diluent slowly down the wall rather than directly onto the cake.
Intended use
Selank is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 11MG
- Molecular formula
- C33H57N11O9
- Molar mass
- 751.9 g/mol
- CAS number
- 129954-34-3
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
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