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Non-Corticotropic ACTH(4-7) Peptide Analogue
Semax
11MG per vial
Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro, in which the ACTH(4-7) fragment — a sequence it shares with α-MSH — is extended at the C-terminus by the biogenic tripeptide Pro-Gly-Pro to slow enzymatic cleavage; the primary literature designates it ACTH(4-7)PGP, though it is also commonly described as an ACTH(4-10) analogue. It is consistently described as non-corticotropic: unlike full-length ACTH, the fragment does not drive adrenal steroidogenesis. Its actions are characterised principally at the level of gene and protein expression rather than at any defined receptor, with concentration-dependent inhibition of the enkephalin-degrading enzymes of human serum being the clearest direct biochemical effect reported.
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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Compound signature
From confirmed structure
813.9g/mol
Molar mass
57atoms
Heavy atoms
Atomic composition
C37H51N9O10S
- C37
- H51
- N9
- O10
- S1
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
Research applications
The most-cited molecular finding is that a single administration in rats raises hippocampal BDNF protein and exon III BDNF mRNA while increasing TrkB tyrosine phosphorylation and TrkB mRNA, placing neurotrophin signalling downstream of the peptide. Genome-wide RNA-sequencing in the rat transient middle cerebral artery occlusion model has been used to characterise its transcriptional profile, reporting suppressed expression of proinflammatory transcripts including Il1a, Il1b, Il6, Ccl3 and Cxcl2 alongside altered expression of neurotransmitter-related genes; complementary proteomic work in the same model examined CREB, MMP-9, c-Fos and JNK in cortical and subcortical tissue, including phosphorylated CREB. Other rodent studies have investigated engagement of dopaminergic and serotonergic systems. Semax and Selank are frequently studied side by side, since both carry the same stabilising Pro-Gly-Pro motif and both were characterised as inhibitors of serum enkephalin-degrading enzymes in the same body of work.
Formulation and handling
The N-terminal methionine is the vulnerable point in this molecule: the thioether side chain is the residue most prone to oxidation, so minimise headspace exposure and repeated reopening of the vial. Semax is freely water-soluble and requires no organic co-solvent, but expect limited persistence in serum-containing media — aminopeptidases and angiotensin-converting enzyme are reported to account for the major part of its hydrolysis in rat serum — so prepare working dilutions fresh.
Intended use
Semax is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 11MG
- Molecular formula
- C37H51N9O10S
- Molar mass
- 813.9 g/mol
- CAS number
- 80714-61-0
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
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