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Pyridine Dinucleotide Redox Coenzyme
NAD+
1000MG per vial
NAD+ (β-nicotinamide adenine dinucleotide, oxidised form) is not a peptide but a pyridine dinucleotide coenzyme — nicotinamide mononucleotide and adenosine monophosphate joined through a pyrophosphate bridge. It occupies two mechanistically distinct roles in the cell. As a redox carrier it cycles reversibly with NADH, accepting a hydride at the C4 position of the nicotinamide ring in glycolysis, β-oxidation and the TCA cycle, with the resulting NADH delivering electrons to complex I of the respiratory chain; separately and irreversibly, it is consumed as a stoichiometric substrate by enzymes that cleave its nicotinamide-ribose glycosidic bond.
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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Compound signature
From confirmed structure
663.4g/mol
Molar mass
44atoms
Heavy atoms
Atomic composition
C21H27N7O14P2
- C21
- H27
- N7
- O14
- P2
Characterised targets
- Sirtuins (SIRT1-SIRT7)
- PARP1/PARP2
- CD38
Research applications
That second, consumptive role is where most current work sits: the sirtuin deacylases (SIRT1-SIRT7), which couple NAD+ hydrolysis to lysine deacetylation and release 2'-O-acetyl-ADP-ribose; the poly(ADP-ribose) polymerases, which build ADP-ribose polymers on chromatin proteins during the DNA damage response; and the ectoenzyme CD38, characterised as a dominant NAD+ glycohydrolase in mammalian tissue and generating nicotinamide, ADP-ribose and cyclic ADP-ribose. In vitro and rodent work has examined how flux through the NAMPT-dependent salvage pathway (nicotinamide to NMN to NAD+) sets the size of the available pool, how the Preiss-Handler and de novo tryptophan routes contribute, and how these classes of consuming enzyme compete for a shared substrate as tissue NAD+ concentrations change with age. It is also a standard reagent in enzymology, used as cofactor in dehydrogenase-coupled spectrophotometric assays and in NAD+-dependent bacterial DNA ligase reactions.
Formulation and handling
Unlike the peptides in this catalogue this is a small-molecule dinucleotide and behaves quite differently — the free acid is markedly hygroscopic, so vials should reach room temperature before opening or condensation will draw water onto the powder and confound weighing. In solution the nicotinamide-ribose glycosidic bond hydrolyses readily and does so faster above neutral pH, so working solutions are better prepared fresh and buffered slightly acidic than stored reconstituted.
Intended use
NAD+ is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 1000MG
- Molecular formula
- C21H27N7O14P2
- Molar mass
- 663.43 g/mol
- CAS number
- 53-84-9
- Molecular targets
- Sirtuins (SIRT1-SIRT7), PARP1/PARP2, CD38
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
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