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N-Acetylated Thymic TLR2/TLR9 Ligand
Thymosin Alpha-1
5MG per vial
Thymosin alpha-1 (thymalfasin) is a 28-residue peptide corresponding to the N-terminal region of prothymosin alpha, residues 2-29 of the precursor, acetylated on its N-terminal serine. It carries no cysteine and therefore no disulfide bonds, and is strongly acidic through a high glutamate and aspartate content, giving it a low isoelectric point. No dedicated high-affinity receptor has been identified for it; the characterised mechanism is engagement of the Toll-like receptors TLR2 and TLR9 on dendritic cells and monocytes, with downstream MyD88-dependent signalling to NF-kappaB.
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Research use only. Supplied for in vitro laboratory research. Not a drug, supplement, cosmetic or medical device, not approved by the TGA, and not for administration to humans or animals. See our research use conditions.
Compound signature
From confirmed structure
3108g/mol
Molar mass
217atoms
Heavy atoms
Atomic composition
C129H215N33O55
- C129
- H215
- N33
- O55
Characterised targets
- TLR2
- TLR9
Sequence
Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH
Research applications
In vitro studies using human and murine dendritic cells have characterised maturation markers, MHC class II and CD80/CD86 surface expression, the cytokine profile of TLR-stimulated cells including IL-12 and type I interferon output, and induction of indoleamine 2,3-dioxygenase with the associated tryptophan catabolism, an effect reported to require TLR9 and type I interferon receptor signalling. Work on T lymphocytes has examined thymocyte differentiation, IL-2 receptor expression and IL-2 production by stimulated peripheral blood mononuclear cells, and separate lines of research have used natural killer cell cytotoxicity assays. Murine models of immunosuppression and of fungal and viral infection have been used to investigate Th1/Th2 polarisation and dendritic cell function.
Formulation and handling
A strongly acidic, cysteine-free peptide that dissolves readily in water and aqueous buffers, with none of the reducing-agent or disulfide-scrambling precautions that other thymic peptides require. Because the isoelectric point is low, dissolution is cleaner in neutral to slightly alkaline buffer than in acidified water; prepare a concentrated aqueous stock first and dilute into the working buffer rather than reconstituting directly into an acidic medium.
Intended use
Thymosin Alpha-1 is supplied exclusively for in vitro and non-clinical scientific research. It is not approved for human or animal therapeutic, diagnostic or medicinal use. All handling and experimentation must be carried out by trained personnel in an appropriately controlled laboratory.
Specification
- Presentation
- Vial
- Labelled strength
- 5MG
- Molecular formula
- C129H215N33O55
- Molar mass
- 3108.3 g/mol
- CAS number
- 62304-98-7
- Molecular targets
- TLR2, TLR9
- Appearance
- Lyophilised powder
- Storage
- 2–8 °C sealed, −20 °C long term
Values describe the compound as supplied. Analytical figures for the material in your vial are on that lot’s certificate, not here.
Certificates of analysis
None published yetEvery lot is tested by an independent laboratory and carries its own certificate. Match the lot number printed on your vial to the certificate — a certificate for a different lot tells you nothing about yours.
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